San Francisco 49ers Schedule 2025. San francisco will face each of their 2023 postseason opponents in the 2025 regular season [green bay (week 12), detroit (week 17) and kansas city (week 7)]. Espn has the full 2025 san francisco 49ers regular season nfl fixtures.

Every week feels like some kind of funeral for the. After another disappointing loss in the super bowl, the san francisco 49ers are ready to enter the 2025 season as potential favorites to bring home the franchise’s sixth world championship.